Detail
| LncRNA Name | ZEB2-AS1 |
| Synonyms | ZEB2-AS1, ZEB2-AS, ZEB2AS, ZEB2NAT |
| Region | GRCh38_2:144518097-144521477 Sequence |
| Ensembl | ENSG00000238057 |
| RefSeq | NR_040248 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Western blot, in vitro knockdown etc. |
| Sample | lung cancer cell lines (H-125, A549, 95D, NCI-H292, H1975), lung cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | ranscript level of ZEB2-AS1 in human lung cancer was markedly upregulated in vivo and in vitro. The knockdown of ZEB2-AS1 in A549 and NCI-H292 cells, and the overexpression of ZEB2-AS1 in H-125 and H1975 cells, altered colony formation and cell proliferative rate, as examined using colony formation and cell proliferation assays. Similarly, the overexpression of ZEB2-AS1 in H-125 and H1975 cells resulted in decreased expression of caspase-3, caspase-9, Bcl-2 and Bax. The results identified the effects of lncRNA ZEB2-AS1 on lung cancer progression through promoting its proliferation and inhibiting cell apoptosis, indicating that ZEB2-AS1 may serve as a novel prognostic factor for the diagnosis and treatment of human lung cancer in the clinic. |
| Pubmed ID | 29552161 |
| Year | 2018 |
| Title | Long non-coding RNA ZEB2-AS1 promotes proliferation and inhibits apoptosis in human lung cancer cells. |
| External Links |
| Links for ZEB2-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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