Detail
| LncRNA Name | CANT1 |
| Synonyms | CANT1, DBQD, DBQD1, SCAN-1, SCAN1, SHAPY |
| Region | GRCh38_17:78991717-79009867 Sequence |
| Ensembl | ENSG00000171302 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | uveal melanoma |
| ICD-0-3 | C69.9 M8720/3 |
| Methods | qPCR, RNAi, RNA-FISH, Cell migration and invasion assay etc. |
| Sample | cell lines (HDF, MUM2B, OCM1, OCM1A, OM431, SP6.5, and 293T) |
| Expression Pattern | down-regulated |
| Function Description | CANT1 significantly reduced tumor metastatic capacity and tumor formation, either in cell culture or in animals harboring tumor xenograft. Intriguingly, XIST lncRNA serves as a potential target of CANT1, and JPX or FTX lncRNA subsequently serves as a contextual hinge to activate a novel CANT1-JPX/FTX-XIST long non-coding (lncing) pathway in UM. Moreover, CANT1 triggers the expression of JPX and FTX by directly binding to their promoters and promoting H3K4 methylation. |
| Pubmed ID | 28330694 |
| Year | 2017 |
| Title | CANT1 lncRNA Triggers Efficient Therapeutic Efficacy by Correcting Aberrant lncing Cascade in Malignant Uveal Melanoma. |
| External Links |
| Links for CANT1 | GenBank HGNC lncrnadb Noncode |
| Links for uveal melanoma | Omim Cosmic |
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