Detail
| LncRNA Name | ZNF750 |
| Synonyms | ZNF750 |
| Region | GRCh38_17:82829435-82840578 Sequence |
| Ensembl | ENSG00000141579 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | head and neck squamous cell carcinoma |
| ICD-0-3 | C76.0 M8070/3 |
| Methods | qPCR, RNAi, Western blot, ChIP, Cell proliferation assay etc. |
| Sample | cell lines (UMSCC1 and 93UV147) |
| Expression Pattern | down-regulated |
| Function Description | In this study, we report that ZNF750 is exclusively deleted, mutated and underexpressed in human SCCs, and low ZNF750 expression is associated with poor survival. Restoration of wildtype, but not mutant ZNF750 protein uniquely inhibited the malignant phenotypes of SCC cells both in vitro and in vivo. Notably, ZNF750 promoted the expression of a long non-coding RNA (TINCR), which mediated both cancer-inhibition and differentiation-induction effects of ZNF750. In addition, ZNF750 potently suppressed cell migration by directly inhibiting the transactivation of LAMC2. |
| Pubmed ID | 27819679 |
| Year | 2016 |
| Title | ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. |
| External Links |
| Links for ZNF750 | GenBank HGNC lncrnadb Noncode |
| Links for head and neck squamous cell carcinoma | Omim Cosmic |
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