Detail
| LncRNA Name | CASC2 |
| Synonyms | CASC2, C10orf5 |
| Region | GRCh38_10:118046279-118210153 Sequence |
| Ensembl | ENSG00000177640 |
| RefSeq | NR_026939 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | melanoma |
| ICD-0-3 | M8720/3 |
| Methods | Microarray, qPCR,Western blot, Luciferase reporter assay |
| Sample | cell line (293T, A375, C8161, HMCB, G361, WM115, MM96L, M14, HaCaT), melanoma tissues |
| Expression Pattern | down-regulated |
| Function Description | CASC2 could efficiently sponge miR-181a,thereby facilitating the expression of PLXNC1. Up-regulation of CASC2 suppressed the cell proliferation and invasion,but induced the apoptosis of melanoma cells. LncRNA CASC2 can promote PLXNC1 expression by sponging miR-181a, thereby inhibiting the proliferation and invasion of melanoma cells,indicating that lncRNA CASC2 functions via the miR-181a/PLXNC1 axis in melanoma. |
| Pubmed ID | 29514220 |
| Year | 2018 |
| Title | Long non-coding RNA CASC2 inhibits tumorigenesis via the miR-181a/PLXNC1 axis in melanoma. |
| External Links |
| Links for CASC2 | GenBank HGNC lncrnadb Noncode |
| Links for melanoma | Omim Cosmic |
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