Detail
| LncRNA Name | CASC2 |
| Synonyms | CASC2, C10orf5 |
| Region | GRCh38_10:118046279-118210153 Sequence |
| Ensembl | ENSG00000177640 |
| RefSeq | NR_026939 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Cell transfection, Dual-luciferase reporter assay, Cell proliferation assay etc. |
| Sample | RCC tissues, cell lines (786-O and A498) |
| Expression Pattern | down-regulated |
| Function Description | The present study confirmed that CASC2 was downregulated in human RCC tissues and human RCC cell lines (786-O and A498). Restoration of CASC2 expression via transfection with a pcDNA3.1(+)-CASC2 vector was able to inhibit cell proliferation and migration in 786-O and A498 cells. Bioinformatics analysis and dual-luciferase reporter assays confirmed that CASC2 was a direct target gene of miR-21. miR-21 was able to decrease the expression of CASC2 in 786-O and A498 cells. Furthermore, overexpression of miR-21 partly abrogated CASC2-mediated inhibition of 786-O and A498 cell proliferation and migration. |
| Pubmed ID | 27222255 |
| Year | 2016 |
| Title | Downregulation of lncRNA CASC2 by microRNA-21 increases the proliferation and migration of renal cell carcinoma cells. |
| External Links |
| Links for CASC2 | GenBank HGNC lncrnadb Noncode |
| Links for renal cell carcinoma | Omim Cosmic |
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