Detail
| LncRNA Name | CASC2 |
| Synonyms | CASC2, C10orf5 |
| Region | GRCh38_10:118046279-118210153 Sequence |
| Ensembl | ENSG00000177640 |
| RefSeq | NR_026939 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | HCC tissues, hepatoma cell lines (HepG2, SMMC-7721, Hep3B, and Huh-7) |
| Expression Pattern | down-regulated |
| Function Description | CASC2 is downregulated in human HCC tissues and HCC cell lines as compared to adjacent non-tumor tissues (NTTs) and a liver cell line, respectively.we determined that CASC2 regulates HCC cell activity by targeting miR-362-5p and thus inhibiting the NF-kB pathway. |
| Pubmed ID | 29319182 |
| Year | 2018 |
| Title | Long noncoding RNA CASC2 regulates hepatocellular carcinoma cell oncogenesis through miR-362-5p/Nf-kB axis. |
| External Links |
| Links for CASC2 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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