Detail
| LncRNA Name | CASC2 |
| Synonyms | CASC2, C10orf5 |
| Region | GRCh38_10:118046279-118210153 Sequence |
| Ensembl | ENSG00000177640 |
| RefSeq | NR_026939 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | astrocytoma |
| ICD-0-3 | M9400/3 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay, Cell migration and invasion assay, ISH etc. |
| Sample | astrocytoma tissues, cell lines (U251 and U87) |
| Expression Pattern | up-regulated |
| Function Description | High CASC2c was positively correlated with astrocytoma progression, and an unfavorable prognosis factor for patients. Knockdown CASC2c inhibited proliferation and tumorgenesis. Overexpression of CASC2c promotes the malignant characteristic of astrocytoma cells.CASC2c directly bound miR-101 and mediated pre-miR-101 processing into mature miR-101, and functions as a competitor of miR-101 target genes such as CPEB1. |
| Pubmed ID | 28252647 |
| Year | 2017 |
| Title | CASC2c as an unfavorable prognosis factor interacts with miR-101 to mediate astrocytoma tumorigenesis. |
| External Links |
| Links for CASC2 | GenBank HGNC lncrnadb Noncode |
| Links for astrocytoma | Omim Cosmic |
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