Detail
| LncRNA Name | CASC7 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Luciferase reporter assay, Western blot etc. |
| Sample | cell lines (SW480, HCT-116) |
| Expression Pattern | down-regulated |
| Function Description | CASC7 overexpression could inhibit cell viability, migration and invasion, and promote apoptosis in CRC cells. CASC7 and ING3 were both a target of miR-21 in CRC cells, and CASC7 could control ING3 expression by regulating miR-21. Moreover, we have found that CASC7 inhibited colon cancer cell proliferation and migration via miR- 21/ING3 axis. These observations suggested that CASC7 played an important role in CRC pathogenesis and may be considered as a novel diagnostic marker of CRC. |
| Pubmed ID | 28954383 |
| Year | 2017 |
| Title | Long non-coding RNA CASC7 inhibits the proliferation and migration of colon cancer cells via inhibiting microRNA-21 |
| External Links |
| Links for CASC7 | GenBank HGNC lncrnadb Noncode |
| Links for colon cancer | Omim Cosmic |
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