Detail
| LncRNA Name | CASC9 |
| Synonyms | CASC9, ESCCAL-1, ESSCAL1, LINC00981, ESCCAL-1 |
| Region | GRCh38_8:75223404-75324741 Sequence |
| Ensembl | ENSG00000249395 |
| RefSeq | NR_103848 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Cell transfection, Western blot, Cell proliferation assay etc. |
| Sample | gastric cancer tissues, cell lines (BGC823 and SGC7901) |
| Expression Pattern | up-regulated |
| Function Description | CASC9 was overexpressed in gastric cancer (GC) compared to normal gastric tissue. Moreover, the expression of CASC9 was even higher in BGC823/DR and SGC7901/DR cells that are resistant to paclitaxel or adriamycin. CASC9 knockdown inhibited proliferation and promoted cell apoptosis In BGC823/DR and SGC7901/DR cells. The invasion potential was also significantly inhibited measured by Transwell assay. In addition, CASC9 knockdown in BGC823/DR and SGC7901/DR cells restored chemosensitivity to paclitaxel and adriamycin. |
| Pubmed ID | 28146436 |
| Year | 2017 |
| Title | Silence of cancer susceptibility candidate 9 inhibits gastric cancer and reverses chemoresistance. |
| External Links |
| Links for CASC9 | GenBank HGNC lncrnadb Noncode |
| Links for gastric cancer | Omim Cosmic |
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