Detail
| LncRNA Name | CASC9 |
| Synonyms | CASC9, ESCCAL-1, ESSCAL1, LINC00981, ESCCAL-1 |
| Region | GRCh38_8:75223404-75324741 Sequence |
| Ensembl | ENSG00000249395 |
| RefSeq | NR_103848 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | esophageal squamous cell cancer |
| ICD-0-3 | |
| Methods | Western blot |
| Sample | esophageal squamous cell carcinoma tissues |
| Expression Pattern | down-regulated |
| Function Description | ESCCAL_1 knockdown significantly inhibited EC9706 cell growth in nude mice.reduced expression of ESCCAL_1 resulted in distinct alterations of relative phosphorylation level of kinases (p-p38a, p-JNK, p-FAK and p-Src), and significant changes of the expression level of apoptosis-related proteins (p53,BAX, Bcl-2 and Caspase-3).Over-expression of ESCCAL_1 activates survival pathway and decrease apoptosis. |
| Pubmed ID | 29416654 |
| Year | 2017 |
| Title | Down-regulation of long non-coding RNA ESCCAL_1 inhibits tumor growth of esophageal squamous cell carcinoma in a xenograft mouse model. |
| External Links |
| Links for CASC9 | GenBank HGNC lncrnadb Noncode |
| Links for esophageal squamous cell cancer | Omim Cosmic |
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