Detail
| LncRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 Sequence |
| Ensembl | ENSG00000247844 |
| RefSeq | NR_108049 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 M9510/3 |
| Methods | qPCR, RNAi, Western blot, Cell migration and invasion assay etc. |
| Sample | RB tissues, cell lines (SO-RB50, Y79 and WERI-RB1) |
| Expression Pattern | up-regulated |
| Function Description | The expression of lncRNA CCAT1 in RB tissues was significantly increased compared with normal tissues. It was also shown that lncRNA CCAT1 in RB SORB50, Y79 and WERI-RB1 cells was significantly higher than that in normal podiatric retina. LncRNA CCAT1 promotes the proliferation migration and invasion, and reduces cell apoptosis of SO-RB50 and Y79 cells, probably through negative modulation of miR-218-5p. |
| Pubmed ID | 28088735 |
| Year | 2017 |
| Title | Long non-coding RNA CCAT1 promotes human retinoblastoma SO-RB50 and Y79 cells through negative regulation of miR-218-5p. |
| External Links |
| Links for CCAT1 | GenBank HGNC lncrnadb Noncode |
| Links for retinoblastoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.