Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name CCAT1
   Synonyms CCAT1, CARLo-5, onco-lncRNA-40
   Region GRCh38_8:127207382-127219268    Sequence
   Ensembl ENSG00000247844
   RefSeq NR_108049
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name laryngeal squamous cell cancer
   ICD-0-3 C32.3  
   Methods qPCR, Western blot
   Sample laryngeal squamous cell carcinoma tissues
   Expression Pattern up-regulated
   Function Description

CCAT1 expression was upregulated in LSCC tissues compared with the normal adjacent tissues. We also demonstrated that CCAT1 overexpression suppressed the expression of let-7 and enhanced the expression of HMGA2 and Myc, the direct target genes of let-7.

   Pubmed ID 27830017
   Year 2016
   Title CCAT1 promotes laryngeal squamous cell carcinoma cell proliferation and invasion
   External Links
   Links for  CCAT1 GenBank       HGNC       lncrnadb       Noncode
   Links for  laryngeal squamous cell cancer Omim       Cosmic

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