Detail
| LncRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 Sequence |
| Ensembl | ENSG00000247844 |
| RefSeq | NR_108049 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP |
| Sample | glioma tissues, cell lines (U87,LN229,HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 expression was significantly increased, while miR-181b decreased,in glioma tissues. Interestingly, miR-181b expression was negatively correlated with the CCAT1 level in glioma samples. Knockdown of CCAT1 notably suppressed proliferation, migration and the epithelial-mesenchymal transition (EMT) process, and promoted the apoptosis of U87 and LN229 glioma cells, which could be enhanced by transfection with miR-181b mimic while it was abolished by anti-miR-181b.CCAT1 may act as a competing endogenous RNA (ceRNA) for miR-181b, regulating the de-repression of FGFR3 and PDGFRa. |
| Pubmed ID | 28475287 |
| Year | 2017 |
| Title | lncRNA CCAT1 Promotes Glioma Tumorigenesis by Sponging miR-181b. |
| External Links |
| Links for CCAT1 | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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