Detail
| LncRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 Sequence |
| Ensembl | ENSG00000247844 |
| RefSeq | NR_108049 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | laryngeal squamous cell cancer |
| ICD-0-3 | C32.3 |
| Methods | qPCR, western blot, Luciferase reporter assays etc. |
| Sample | laryngeal squamous cell cancer tissues, cell lines (AMC-HN-8 and TU212) |
| Expression Pattern | up-regulated |
| Function Description | The results showed that expressions of colon cancer-associated transcript-1 and zinc finger protein, X-linked were significantly higher while microRNA-218 expression was significantly lower in the laryngeal squamous cell cancer tissues than those in the adjacent normal tissues. Moreover, a novel CCAT1-miR-218-ZFX regulatory axis was demonstrated in the proliferation and invasion of LSCC cells in vitro and in vivo. |
| Pubmed ID | 28631575 |
| Year | 2017 |
| Title | Long non-coding RNA CCAT1/miR-218/ZFX axis modulates the progression of laryngeal squamous cell cancer |
| External Links |
| Links for CCAT1 | GenBank HGNC lncrnadb Noncode |
| Links for laryngeal squamous cell cancer | Omim Cosmic |
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