Detail
| LncRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 Sequence |
| Ensembl | ENSG00000247844 |
| RefSeq | NR_108049 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Luciferase reporter assay, RIP |
| Sample | Breast cancer tissues, human breast cancer cell lines (MCF-7 and MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1 was up-regulated and miR-148b was down-regulated in radioresistant breast cancer tissues compared with radiosensitive breast cancer tissues.CCAT1 down-regulation reduced colony formation rates and caspase3 activity in breast cancer cells under irradiation. Moreover, CCAT1 could negatively regulate miR-148b expression. Furthermore, overexpression of miR-148b suppressed colony survival fraction and caspase3 expression under irradiation in breast cancer cells, which was exacerbated by CCAT1 knockdown. |
| Pubmed ID | 29024383 |
| Year | 2017 |
| Title | Down-regulation of LncRNA CCAT1 enhances radiosensitivity via regulating miR-148b in breast cancer. |
| External Links |
| Links for CCAT1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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