we found that the levels of HOTAIR and CCAT1 were significantly higher in plasma of CRC patients than that of the healthy control. Moreover, the levels of lincRNA-p21 were obviously decreased in plasma of CRC patients as compared to those of healthy control. There was highly correlated for CCAT1, HOTAIR and lincRNA-p21 in plasma and serum. By receiver operating characteristic curve (ROC) analysis, plasma CCAT1 provided the higher diagnostic performance for detection of CRC. Moreover, CCAT1 combining with HOTAIR could provide a more effective diagnosis performance. Most importantly, this combination was effective to detect CRC at an early stage (85%). In conclusion, our results demonstrated that increased plasma HOTAIR and CCAT1 could be used as a predictive biomarker for CRC screening, and that combination of HOTAIR and CCAT1 had a higher positive diagnostic rate of CRC than HOTAIR or CCAT1 alone