Detail
| LncRNA Name | CCAT1 |
| Synonyms | CCAT1, CARLo-5, onco-lncRNA-40 |
| Region | GRCh38_8:127207382-127219268 Sequence |
| Ensembl | ENSG00000247844 |
| RefSeq | NR_108049 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Western blot, RNAi, Luciferase reporter assay |
| Sample | hepatocellular carcinoma tissues, cell lines (MHCC97H, MHCC97L, Hep3B, and SMCC-7721) |
| Expression Pattern | up-regulated |
| Function Description | In this study, we found that the long non-coding RNA colon cancerâ??associated transcript 1 was upregulated in hepatocellular carcinoma tissues (p<0.05), and high colon cancer-associated transcript 1 expression level was positively associated with tumor volume (p<0.05) and American Joint Committee on Cancer stage (p<0.05) in hepatocellular carcinoma patients. These data demonstrated that the colon cancer-associated transcript 1/miR-490-3p/cyclin-dependent kinase 1 regulatory pathway promotes the progression of hepatocellular carcinoma. |
| Pubmed ID | 28381168 |
| Year | 2017 |
| Title | Long non-coding RNA colon cancerâ??associated transcript 1 functions as a competing endogenous RNA to regulate cyclin-dependent kinase 1 expression by sponging miR-490-3p in hepatocellular carcinoma progression |
| External Links |
| Links for CCAT1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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