Detail
| LncRNA Name | CCAT1-L |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | cell lines (HT29, HCT116) |
| Expression Pattern | up-regulated |
| Function Description | CCAT1-L plays a role in MYC transcriptional regulation and promotes long-range chromatin looping. Importantly, the CCAT1-L locus is located within a strong super-enhancer and is spatially close to MYC. Knockdown of CCAT1-L reduced long-range interactions between the MYC promoter and its enhancers. In addition, CCAT1-L interacts with CTCF and modulates chromatin conformation at these loop regions. |
| Pubmed ID | 24662484 |
| Year | 2014 |
| Title | Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. |
| External Links |
| Links for CCAT1-L | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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