Detail
| LncRNA Name | CCAT2 |
| Synonyms | CCAT2, LINC00873, NCCP1 |
| Region | GRCh38_8:127400399-127402150 Sequence |
| Ensembl | ENSG00000280997 |
| RefSeq | NR_109834 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | pancreatic ductal adenocarcinoma |
| ICD-0-3 | C25.3 M8500/3 |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay |
| Sample | PDAC tissues, pancreatic cancer cell line (PANC-1, SW1990, PC-3) |
| Expression Pattern | up-regulated |
| Function Description | CCAT2 was up-regulated in PDAC cell lines, as compared with normal pancreatic cells. Silencing of CCAT2 inhibited cell proliferation and invasion in PANC-1 cells in vitro, and attenuated tumorigenesis of PANC-1 xenograft in vivo. Furthermore, CCAT2 was regulated by KRAS through MEK/ERK signaling pathway. |
| Pubmed ID | 29298720 |
| Year | 2018 |
| Title | CCAT2 is an oncogenic long non-coding RNA in pancreatic ductal adenocarcinoma. |
| External Links |
| Links for CCAT2 | GenBank HGNC lncrnadb Noncode |
| Links for pancreatic ductal adenocarcinoma | Omim Cosmic |
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