Our results showed that CCAT2 functioning as a potential oncogene was upregulated in oral squamous cell carcinoma. CCAT2 with high expression level was correlated with poor differentiation, higher T stage, and clinical stage, which made CCAT2 to be a prognostic biomarker in oral squamous cell carcinoma. LiCl-activated Wnt/B-catenin signaling pathway could partly restore the CCAT2-mediated malignant biological behaviors of oral squamous cell carcinoma cells by suppressing B-catenin, CCND1, and MYC and activating glycogen synthase kinase 3 beta expression. However, CCAT2 expression was not associated with other parameters such as gender ( p = 0.5057), age ( p = 0.8907), smoking ( p = 0.2778), drinking ( p = 0.5626), position ( p = 0.1337), and N stage ( p = 0.1138) in OSCC (Table 1). These findings pro- vided initial evidence that CCAT2 may play an important role in the OSCC progression. Furthermore, Kaplanâ??Meier survival analysis revealed that patients with high CCAT2 expression level had a significantly poorer overall survival than those with low expression level.