Lnc2Cancer

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   LncRNA Name CCAT2
   Synonyms CCAT2, LINC00873, NCCP1
   Region GRCh38_8:127400399-127402150    Sequence
   Ensembl ENSG00000280997
   RefSeq NR_109834
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name colon cancer
   ICD-0-3 C18  
   Methods qPCR etc.
   Sample cell lines (HCT-116, HT-29)
   Expression Pattern up-regulated
   Function Description

We have observed that modulated expression of CCAT2 regulates the expression of miR-145 in colon cancer HCT-116 and HT-29 cells. Knockout of CCAT2 increases miR-145 and negatively regulates miR-21 in HCT-116 cells, impairs proliferation and differentiation. In contrast, stable up-regulation of CCAT2 decreases mature miR-145 and increases the expression of several CSC markers in colon cancer cells. We have also observed that CCAT2 is enriched in the nucleus and correlates with the expression of pre-miR-145 but not pre-miR-21 in HCT-116 cells. These results indicate CCAT2 selectively blocks miR-145 maturation by inhibiting pre-miR-145 export to cytoplasm. Further, we revealed that CCAT2 blocks cleavage of pre-miR-145 by Dicer in vitro.

   Pubmed ID 28964256
   Year 2017
   Title A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells
   External Links
   Links for  CCAT2 GenBank       HGNC       lncrnadb       Noncode
   Links for  colon cancer Omim       Cosmic

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