CCAT2 was upregulated in HCC cell lines and cancerous tissues. The level of CCAT2 was positively associated with tumor-node-metastasis stages and vessel invasion. Moreover, we also found that knockdown of CCAT2 expression reduced cell migration and invasion in vitro. We further demonstrated that CCAT2 played a key role in enhancing the epithelial-mesenchymal transition (EMT) through the regulation of vimentin, E-cadherin and transcription factor snail2 expression.