Detail
| LncRNA Name | CCDC26 |
| Synonyms | CCDC26, RAM, MGC27434 |
| Region | GRCh38_8:128634199-129683679 Sequence |
| Ensembl | ENSG00000229140 |
| RefSeq | NR_130917 |
| Circulating | ✘ |
| Drug-resisitant | ✔ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | gastrointestinal stromal tumor |
| ICD-0-3 | C16 M8936/0 |
| Methods | qRT-PCR, Western blot, in vitro knockdown |
| Sample | GIST cell lines (GIST-882 and GIST-T1) |
| Expression Pattern | differential expression |
| Function Description | We found that human GIST-882 cells with lower CCDC26 expression were less sensitive to imatinib compared with GIST-T1 cells with higher CCDC26 expression. CCDC26 expression decreased in a time-dependent manner in the presence of imatinib. Moreover, small interfering RNA (siRNA) knockdown of CCDC26 increased GIST cell sensitivity to imatinib. The RNA pull-down experiment showed that CCDC26 can interact with c-KIT and that CCDC26 knockdown can upregulate c-KIT expression. We also found that inhibiting c-KIT induced resistance to imatinib. |
| Pubmed ID | 29423012 |
| Year | 2018 |
| Title | CCDC26 knockdown enhances resistance of gastrointestinal stromal tumor cells to imatinib by interacting with c-KIT. |
| External Links |
| Links for CCDC26 | GenBank HGNC lncrnadb Noncode |
| Links for gastrointestinal stromal tumor | Omim Cosmic |
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