Detail
| LncRNA Name | CNALPTC1 |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | M8260/3 |
| Methods | Microarray, qRT-PCR, Western blot, Luciferase reporter assay, RIP |
| Sample | PTC tissues, PTC cell lines (TPC-1 and IHH-4) |
| Expression Pattern | up-regulated |
| Function Description | The genomic copy number of CNALPTC1 is amplified and CNALPTC1 expression level is up-regulated in PTC.CNALPTC1 physically associates to miR-30 family and down-regulates miR-30 expression. Furthermore, CNALPTC1 up-regulates the expression of miR-30 targets, such as BCL9, SNAI1, and VIM. The mutation of miR-30 binding site on CNALPTC1 or overexpression of miR-30 abrogates the oncogenic roles of CNALPTC1 in PTC. |
| Pubmed ID | 29416932 |
| Year | 2018 |
| Title | Long noncoding RNA CNALPTC1 promotes cell proliferation and migration of papillary thyroid cancer via sponging miR-30 family. |
| External Links |
| Links for CNALPTC1 | GenBank HGNC lncrnadb Noncode |
| Links for papillary thyroid cancer | Omim Cosmic |
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