Detail
| LncRNA Name | ADAMTS9-AS2 |
| Synonyms | lncADAMTS9-AS2 |
| Region | GRCh38_3:64684909-65011468 Sequence |
| Ensembl | ENSG00000241684 |
| RefSeq | NR_038264 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | lung cancer |
| ICD-0-3 | C34 |
| Methods | Microarray, qPCR, Western blot etc |
| Sample | lung cancer tissues, cell lines (A549, SPC-A1, H23 and NCI-H520) |
| Expression Pattern | down-regulated |
| Function Description | lncADAMTS9-AS2 was lowly expressed in lung cancer tissues.High expression of ADAMTS9-AS2 in lung cancer cells significantly reduced proliferation ability and inhibited migration, as well as elevating their apoptosis rate.In vivo assay found that ADAMTS9-AS2 suppressed the lung tumor growth. Bioinformatics predicted that miR-223-3p bound directly to the ADAMTS9-AS2 and TGFBR3, which was later confirmed by luciferase reporter system.ADAMTS9-AS2 transfection increased TGFBR3 mRNA and protein expressions in lung cancer cells, but miR-223-3p transfection significantly decreased them. Besides,miR-223-3p induced cellular apoptosis while TGFBR3 group showed the complete opposite effect. It was proved that ADAMTS9-AS2 and TGFBR3 were the direct genes of miR-223-3p. MiR-223-3p promotes proliferation, migration and invasion of lung cancer cells by targeting TGFBR3. |
| Pubmed ID | 29707897 |
| Year | 2018 |
| Title | Upregulated lncRNA ADAMTS9-AS2 suppresses progression of lung cancer through inhibition of miR-223-3p and promotion of TGFBR3. |
| External Links |
| Links for ADAMTS9-AS2 | GenBank HGNC lncrnadb Noncode |
| Links for lung cancer | Omim Cosmic |
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