Detail
| LncRNA Name | CPS1-IT1 |
| Synonyms | CPS1-IT1, CPS1-IT, CPS1IT, CPS1IT1, PRO0132 |
| Region | GRCh38_2:210617571-210619876 Sequence |
| Ensembl | ENSG00000280837 |
| RefSeq | NR_002763 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | intrahepatic cholangiocarcinoma |
| ICD-0-3 | C22 M8160/3 |
| Methods | qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | ICC tissues, cell lines (L-02, Huh-7, Bel-7402) |
| Expression Pattern | up-regulated |
| Function Description | Carbamoyl-phosphate synthase 1 (CPS1) and its lncRNA CPS1 intronic transcript 1 (CPS1-IT1) were observed to be upregulated in ICC. CPS1 and CPS1-IT1 were co-upregulated in ICC tissues compared with non-cancerous tissues. Knockdown of CPS1 andor CPS1-IT1 reduced the proliferation and increased the apoptosis of ICC-9810 cells. Additionally, clinical analysis indicated that CPS1 and CPS1-IT1 were associated with poor liver function and reduced survival rates when the relative expression values were greater than 4 in cancer tissues. |
| Pubmed ID | 26499888 |
| Year | 2015 |
| Title | Co-expression of the carbamoyl-phosphate synthase 1 gene and its long non-coding RNA correlates with poor prognosis of patients with intrahepatic cholangiocarcinoma. |
| External Links |
| Links for CPS1-IT1 | GenBank HGNC lncrnadb Noncode |
| Links for intrahepatic cholangiocarcinoma | Omim Cosmic |
CopyRight © College of Bioinformatics Science and Technology, Harbin Medical University, China.