Detail
| LncRNA Name | CPS1-IT1 |
| Synonyms | CPS1-IT1, CPS1-IT, CPS1IT, CPS1IT1, PRO0132 |
| Region | GRCh38_2:210617571-210619876 Sequence |
| Ensembl | ENSG00000280837 |
| RefSeq | NR_002763 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay |
| Sample | colorectal cancerous tissues, cell lines (LoVo, SW620, SW480, LS174T, HCT116 and HT29, HUVEC) |
| Expression Pattern | down-regulated |
| Function Description | Expression of CPS1-IT1 were significantly reduced, while HIF-1a and LC3-II were increased in CRC tissues and cell lines.CPS1-IT1 suppresses EMT and autophagy by inhibiting the activation of HIF-1a in CRC.lncRNA CPS1-IT might suppresses metastasis and EMT by inhibiting hypoxia induced autophagy through inactivation of HIF-1a in CRC. |
| Pubmed ID | 29017924 |
| Year | 2017 |
| Title | LncRNA CPS1-IT1 suppresses EMT and metastasis of colorectal cancer by inhibiting hypoxia-induced autophagy through inactivation of HIF-1a |
| External Links |
| Links for CPS1-IT1 | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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