Detail
| LncRNA Name | CPSF6 |
| Synonyms | CleavageandPolyadenylationFactor-6 |
| Region | GRCh38_12:69239537-69274358 Sequence |
| Ensembl | ENSG00000111605 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc. |
| Sample | BC tissues, cell lines (MDA-MB-231, MDA-MB-453, SKBR3 and BT474) |
| Expression Pattern | up-regulated |
| Function Description | Aggressive breast cancer cells require CPSF6 for viability and tumorigenesis. CPSF6 and paraspeckles core proteins are associated with poor outcome in breast cancer. Prolactin hormone reprograms cells to suppress CPSF6 interaction with paraspeckles and ADAR1, A-I RNA editing machinery. CPSF6 and all core paraspeckles proteins to be overexpressed in human breast cancer cases and their expression to correlate with poor patient outcomes. the important role and contribution of CPFS6 to survival and tumor formation of aggressive breast cancer cells. |
| Pubmed ID | 28673861 |
| Year | 2017 |
| Title | CPSF6 is a Clinically Relevant Breast Cancer Vulnerability Target: Role of CPSF6 in Breast Cancer. |
| External Links |
| Links for CPSF6 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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