Detail
| LncRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 Sequence |
| Ensembl | ENSG00000245694 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | M9823/3 |
| Methods | qPCR |
| Sample | CLL peripheral blood mononuclear cells, CLL cell lines (HG3, MEC1), Burkitt lymphoma B cell line (RAMOS) |
| Expression Pattern | differential expression |
| Function Description | Finally, two novel lncRNAs (hypermethylated CRNDE and hypomethylated AC012065.7) were validated in an independent CLL sample cohort (48 samples) compared with 6 normal sorted B cell samples using quantitative pyrosequencing analysis.The methylation levels showed an inverse correlation to gene expression levels analyzed by real-time quantitative PCR. Notably, survival analysis revealed that hypermethylation of CRNDE and hypomethylation of AC012065.7 correlated with an inferior outcome |
| Pubmed ID | 27777635 |
| Year | 2016 |
| Title | Global DNA methylation profiling reveals new insights into epigenetically deregulated protein coding and long noncoding RNAs in CLL |
| External Links |
| Links for CRNDE | GenBank HGNC lncrnadb Noncode |
| Links for chronic lymphocytic leukemia | Omim Cosmic |
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