Detail
| LncRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 Sequence |
| Ensembl | ENSG00000245694 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR |
| Sample | breast cancer tissues, cell lines (MCF-7, MDA-MB-231, MDA-MB-468 and BT-549) |
| Expression Pattern | up-regulated |
| Function Description | CRNDE expression is remarkably up-regulated in BC tissue specimens and cell lines in comparison to corresponding normal tissues and normal human breast epithelial cells. Up-regulated CRNDE expression was greatly associated with larger tumor size, advanced TNM stage and unfavorable prognosis of BC patients. We uncovered that miR-136 is a bona fide binding target of CRNDE, and that up-regulation of CRNDE promoted the mRNA and protein expressions of B-catenin, c-myc and cyclinD1. |
| Pubmed ID | 28469804 |
| Year | 2017 |
| Title | Long noncoding RNA CRNDE activates Wnt/B-catenin signaling pathway through acting as a molecular sponge of microRNA-136 in human breast cancer |
| External Links |
| Links for CRNDE | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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