Detail
| LncRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 Sequence |
| Ensembl | ENSG00000245694 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | M9861/3 |
| Methods | qPCR |
| Sample | bone marrow tissues, acute myeloid leukemia cell line (U937) |
| Expression Pattern | up-regulated |
| Function Description | The expression of lncRNA-CRNDE in patients with AML and U937 cells was significantly higher than that in non-malignant hematological controls. Results of clinical data showed that the expression of lncRNA-CRNDE was associated with the classification and total survival of myeloid leukemia in clinical patients. After transfection of siRNA-CRNDE, the proliferation and cloning ability of U937 cells decreased, while the apoptosis increased (p < 0.01) and cells were arrested in G0-G1 phase.the expression of lncRNA-CRNDE might play an essential role in promoting the proliferation of U937 cells. |
| Pubmed ID | 29461608 |
| Year | 2018 |
| Title | High expression of lnc-CRNDE presents as a biomarker for acute myeloid leukemia and promotes the malignant progression in acute myeloid leukemia cell line U937. |
| External Links |
| Links for CRNDE | GenBank HGNC lncrnadb Noncode |
| Links for acute myeloid leukemia | Omim Cosmic |
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