Detail
| LncRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 Sequence |
| Ensembl | ENSG00000245694 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR etc. |
| Sample | NSCLC cancer tissues, cell lines (A549, PC-9 and SK-MES-1) |
| Expression Pattern | up-regulated |
| Function Description | The expression of CRNDE was significantly up-regulated in NSCLC patients and cells. In addition, both loss and gain function assays revealed that CRNDE promoted NSCLC cell proliferation and growth both in vitro and in vivo. Moreover, CRNDE regulated the cell cycle transition from G0/G1 stage to S stage and modulated the expression of CDK4, CDK6 and CCNE1. CRNDE activated PI3K/AKT signaling in NSCLC cell lines. CRNDE was highly expressed in NSCLC malignant tissues and the heightened CRNDE strongly promoted NSCLC cell proliferation and growth through activating PI3K/AKT signaling; our results shed a light on utilizing CRNDE as a potential novel therapeutic target for the treatment of NSCLC. |
| Pubmed ID | 28477368 |
| Year | 2017 |
| Title | Highly expressed long non-coding RNA CRNDE promotes cell proliferation through PI3K/AKT signalling in non-small cell lung carcinoma. |
| External Links |
| Links for CRNDE | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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