Detail
| LncRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 Sequence |
| Ensembl | ENSG00000245694 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | qPCR, RNAi, Western blot, RIP, Luciferase reporter assay, Cell proliferation assay etc. |
| Sample | glioma tissues, cell lines (U87, U251, HEK 293T) |
| Expression Pattern | up-regulated |
| Function Description | CRNDE overexpression facilitated cell proliferation, migration, and invasion, while inhibited glioma cells apoptosis. Moreover, CRNDE promoted cell malignant behavior by decreasing miR-384 expression. Knockdown of CRNDE combined with overexpression of miR-384 restrained tumor growth and exhibit high survival in nude mice. |
| Pubmed ID | 27058823 |
| Year | 2016 |
| Title | CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis. |
| External Links |
| Links for CRNDE | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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