Detail
| LncRNA Name | CTB-89H12.4 |
| Synonyms | CTB-89H12.4 |
| Region | GRCh38_5:149494314-149504670 Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, RIP, Dual-luciferase reporter assay etc. |
| Sample | cell lines (DMEM, RPMI-1640, McCoy's 5A) |
| Expression Pattern | up-regulated |
| Function Description | We confirm the tumour-suppressive function of two lncRNAs (TUG1 and CTB-89H12.4) and their regulation of PTEN expression in prostate cancer. Surprisingly, one of the two lncRNAs, TUG1, was previously known for its function in polycomb repressive complex 2 (PRC2)-mediated transcriptional regulation, suggesting its sub-cellular localization-dependent function. Our findings not only suggest an important role of lncRNA-mediated sponge regulation in cancer, but also underscore the critical influence of cytoplasmic localization on the efficacy of a sponge lncRNA. |
| Pubmed ID | 26975529 |
| Year | 2016 |
| Title | Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer |
| External Links |
| Links for CTB-89H12.4 | GenBank HGNC lncrnadb Noncode |
| Links for prostate cancer | Omim Cosmic |
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