Detail
| LncRNA Name | DANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 Sequence |
| Ensembl | ENSG00000226950 |
| RefSeq | NR_024031 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, RNAi, Western blot, RNA pull-down assay etc. |
| Sample | CRC tissues, cell lines (M5, HCT116, lovo, SW620, Caco-2, DLD1, HT29 and SW480) |
| Expression Pattern | up-regulated |
| Function Description | ANCR, EZH2 and H3K27me3 expressions were up-regulated in CRC tissues and SW620 cells. After transfected with ANCR-siRNA, SW620 cells showed decreased ANCR expression and EZH2 mRNA and protein expressions. According to the results of RNA pull-down and co-IP assays, ANCR could specifically bind to EZH2. The results of Trans-well and cell scratch tests showed that when ANCR expression was decreased, the invasion and migration abilities of SW620 cells significantly declined. |
| Pubmed ID | 27983539 |
| Year | 2017 |
| Title | LncRNA-ANCR down-regulation suppresses invasion and migration of colorectal cancer cells by regulating EZH2 expression. |
| External Links |
| Links for DANCR | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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