Detail
| LncRNA Name | DANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 Sequence |
| Ensembl | ENSG00000226950 |
| RefSeq | NR_024031 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, RIP etc. |
| Sample | pancreatic carcinoma tissues, cell lines (HT29, HCT116, SW480, LOVO and e NCM460) |
| Expression Pattern | up-regulated |
| Function Description | DANCR was highly expressed and correlated with proliferation and metastasis in CRC.In addition, we demonstrated that DANCR and HSP27 were both targets of microRNA-577 (miR-577) and shared the same binding site.Furthermore,DANCR promoted HSP27 expression and its mediation of proliferation/metastasis via miR-577 sponging. Finally, using an in vivo study, we confirmed that overexpression of DANCR promoted CRC tumor growth and liver metastasis. |
| Pubmed ID | 29717105 |
| Year | 2018 |
| Title | Long noncoding RNA DANCR promotes colorectal cancer proliferation and metastasis via miR-577 sponging. |
| External Links |
| Links for DANCR | GenBank HGNC lncrnadb Noncode |
| Links for colorectal cancer | Omim Cosmic |
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