Detail
| LncRNA Name | DBH-AS1 |
| Synonyms | DBH-AS1, NCRNA00118, BPR |
| Region | GRCh38_9:133654586-133657313 Sequence |
| Ensembl | ENSG00000225756 |
| RefSeq | NR_002783 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, RNAi, Western blot etc. |
| Sample | HCC tissues, cell lines (HepG2, SMMC-7721, Hep3B, MHCC97H, SK-Hep1) |
| Expression Pattern | up-regulated |
| Function Description | The levels of DBH-AS1 were positively correlated with hepatitis B surface antigen (HBsAg) and tumor size in HCC tissues. Overexpression of DBH-AS1 induced cell cycle progression by accelerating G1/S and G2/M transition concomitantly with upregulation of CDK6, CCND1, CCNE1 and downregulation of p16, p21 and p27. We also provide evidence that DBH-AS1 could be significantly induced by HBx protein and markedly down-regulated by p53. Thus, we concluded that DBH-AS1 can be induced by HBx and inactivated by p53, and consequently promote cell proliferation and cell survival through activation of MAPK signaling in HCC. |
| Pubmed ID | 26393879 |
| Year | 2015 |
| Title | HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma. |
| External Links |
| Links for DBH-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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