Detail
| LncRNA Name | DGCR5 |
| Synonyms | DGCR5, LINC00037, NCRNA00037 |
| Region | GRCh38_22:18970514-18994628 Sequence |
| Ensembl | ENSG00000237517 |
| RefSeq | NR_002733 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc. |
| Sample | cell lines (A549, H460, H1299 and HEK-293T) |
| Expression Pattern | up-regulated |
| Function Description | DGCR5 was up-regulated in the enriched CSCs of NSCLC. DGCR5 can inhibit the stemness of NSLCL while overexpression of DGCR5 promoted CSC-like traits.In addition, miR-330-5p was predicted as target of DGCR.Meanwhile,miR-330-5p was decreased in CSCs of NSCLC.miR-330-5p mimics repressed the stemness while miR-330-5p inhibition enhanced CSC-like properties by targeting CD44.Taken these together,DGCR5 can act as a crucial regulator of CSCs in NSCLC by modulating miR-330-5p/CD44 axis. |
| Pubmed ID | 29663359 |
| Year | 2018 |
| Title | LncRNA DGCR5 contributes to CSC-like properties via modulating miR-330-5p/CD44 in NSCLC. |
| External Links |
| Links for DGCR5 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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