Detail
| LncRNA Name | DLEU2 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP6 |
| Region | GRCh38_13:49982552-50125720 Sequence |
| Ensembl | ENSG00000231607 |
| RefSeq | NR_002612 |
| Circulating | ✔ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✔ |
| TF | ✘ |
| Methylation | ✔ |
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | M9823/3 |
| Methods | microarray, qPCR, RNAi, ChIP, Luciferase reporter assay etc. |
| Sample | blood |
| Expression Pattern | up-regulated |
| Function Description | In contrast, the lncRNA genes DLEU1 and variant DLEU2/Alt1 that display DNA-hypomethylation at their 5' ends are significantly upregulated in CLL cells. We found a significant inverse correlation of gene expression of the lncRNA genes DLEU1 and the DLEU2 variant Alt1 with DNA-methylation levels in regions D6 and E6 that are localized at their transcriptional start sites. |
| Pubmed ID | 23593011 |
| Year | 2013 |
| Title | Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB. |
| External Links |
| Links for DLEU2 | GenBank HGNC lncrnadb Noncode |
| Links for chronic lymphocytic leukemia | Omim Cosmic |
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