Detail
| LncRNA Name | DLEU2 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP6 |
| Region | GRCh38_13:49982552-50125720 Sequence |
| Ensembl | ENSG00000231607 |
| RefSeq | NR_002612 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | myeloma |
| ICD-0-3 | C42.1 M9732/3 |
| Methods | qPCR, Western blot, Northern blot, Luciferase reporter assay etc. |
| Sample | myeloma tissues, cell lines (HEK293, U2OS etc.) |
| Expression Pattern | down-regulated |
| Function Description | The microRNAs miR-15a and miR-16-1 are downregulated in multiple tumor types and are frequently deleted in chronic lymphocytic leukemia (CLL), myeloma and mantle cell lymphoma. DLEU2 negatively regulates the G1 Cyclins E1 and D1 through miR-15a/miR-16-1 and provide evidence that these oncoproteins are subject to miR-15a/miR-16-1-mediated repression under normal conditions. We also demonstrate that DLEU2 overexpression blocks cellular proliferation and inhibits the colony-forming ability of tumor cell lines in a miR-15a/miR-16-1-dependent way. |
| Pubmed ID | 19591824 |
| Year | 2009 |
| Title | DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-3. |
| External Links |
| Links for DLEU2 | GenBank HGNC lncrnadb Noncode |
| Links for myeloma | Omim Cosmic |
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