Detail
| LncRNA Name | DLEU2 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP6 |
| Region | GRCh38_13:49982552-50125720 Sequence |
| Ensembl | ENSG00000231607 |
| RefSeq | NR_002612 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | chronic lymphocytic leukemia |
| ICD-0-3 | M9823/3 |
| Methods | qPCR, Northern blot etc. |
| Sample | cell lines (I83E95) |
| Expression Pattern | down-regulated |
| Function Description | Here, we demonstrate that deletion in mice of the 13q14-minimal deleted region (MDR), which encodes the DLEU2/miR-15a/16-1 cluster, causes development of indolent B cell-autonomous, clonal lymphoproliferative disorders, recapitulating the spectrum of CLL-associated phenotypes observed in humans. miR-15a/16-1-deletion accelerates the proliferation of both human and mouse B cells by modulating the expression of genes controlling cell-cycle progression. |
| Pubmed ID | 20060366 |
| Year | 2010 |
| Title | The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. |
| External Links |
| Links for DLEU2 | GenBank HGNC lncrnadb Noncode |
| Links for chronic lymphocytic leukemia | Omim Cosmic |
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