Detail
| LncRNA Name | DLX6-AS1 |
| Synonyms | DLX6-AS1, DLX6-AS, DLX6AS, Evf-2, NCRNA00212, FLJ34048 |
| Region | GRCh38_7:96955141-97014065 Sequence |
| Ensembl | ENSG00000231764 |
| RefSeq | NR_015448 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | hepatocellular carcinoma tissues, cell lines (MHCC97L, HCCLM3, HepG2, Hep3B, Huh7, LO2) |
| Expression Pattern | up-regulated |
| Function Description | DLX6-AS1 expression level was up-regulated in 60 cases of HCC tissue samples compared with adjacent normal tissue.the aberrant overexpression of DLX6-AS1 indicated the poor prognosis of HCC patients. DLX6-AS1 knockdown inhibited the proliferation, migration and invasion of HCC cells in vitro, and decreased the tumor growth in vivo.miR-203a potentially targeted DLX6-AS1 3'-UTR, suggesting the interaction between miR-203a and DLX6-AS1. Furthermore, miR-203a also targeted MMP-2 mRNA 3'-UTR. |
| Pubmed ID | 29145165 |
| Year | 2017 |
| Title | Long non-coding RNA DLX6-AS1 aggravates hepatocellular carcinoma carcinogenesis by modulating miR-203a/MMP-2 pathway. |
| External Links |
| Links for DLX6-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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