Lnc2Cancer

Experimentally Supported Human LncRNA and Cancer Associations Database

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   LncRNA Name AFAP1-AS1
   Synonyms AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740, MGC10981
   Region GRCh38_4:7754090-7778928    Sequence
   Ensembl ENSG00000272620
   RefSeq NR_026892
   Circulating
   Drug-resisitant
   Prognostic
   MiRNA
   Variant
   TF
   Methylation
   Cancer Name breast cancer
   ICD-0-3 C50  
   Methods qPCR
   Sample breast cancer tissues, cell lines(MDA-MB-40 231 and MCF-7)
   Expression Pattern up-regulated
   Function Description

both genes were significantly down-regulated in Ki-67 negative tumor samples. The observed up-regulation of AFAP1-AS1 in tumor samples compared with ANCTs implies its involvement in breast cancer pathogenesis and potentiates it as a biomarker or therapeutic target.

   Pubmed ID 29439313
   Year 2018
   Title Expression analysis of AFAP1-AS1 and AFAP1 in breast cancer.
   External Links
   Links for  AFAP1-AS1 GenBank       HGNC       lncrnadb       Noncode
   Links for  breast cancer Omim       Cosmic

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