Detail
| LncRNA Name | DNM3OS |
| Synonyms | DNM3OS, DNM3-AS1, MIR199A2HG |
| Region | GRCh38_1:172136531-172144794 Sequence |
| Ensembl | ENSG00000230630 |
| RefSeq | NR_038397 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✔ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR etc. |
| Sample | cell lines (type I, type II etc.) |
| Expression Pattern | up-regulated |
| Function Description | The characterization of Twist1 as a regulator of a unique miRNA cluster responsible for the regulation of the IKKb/NFkB and PTEN/AKT pathways and its association of ovarian CSC differentiation. Our data suggest that Twist1 may be an important regulator of 'stemness' in EOC cells. The regulation of MIR199A2/214 expression may be used as a potential therapeutic approach in EOC patients. |
| Pubmed ID | 20400975 |
| Year | 2010 |
| Title | TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. |
| External Links |
| Links for DNM3OS | GenBank HGNC lncrnadb Noncode |
| Links for epithelial ovarian cancer | Omim Cosmic |
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