Detail
| LncRNA Name | DSCAM-AS1 |
| Synonyms | DSCAM-AS1, M41 |
| Region | GRCh38_21:40383083-40385358 Sequence |
| Ensembl | ENSG00000235123 |
| RefSeq | NR_038896 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RNA-seq, qPCR, RNAi, ChIP, Cell proliferation assay etc. |
| Sample | cell lines (MCF-7, HEK 293T, MDA-MB-231, SK-BR-3 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The most abundant AER-lncRNA, DSCAM-AS1, is expressed in ERa+ breast carcinoma, but not in pre-neoplastic lesions, and correlates inversely with EMT markers. Down-regulation of DSCAM-AS1 recapitulated, in part, the effect of silencing ERa, i.e. growth arrest and induction of EMT markers. |
| Pubmed ID | 26621851 |
| Year | 2016 |
| Title | Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer. |
| External Links |
| Links for DSCAM-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for breast cancer | Omim Cosmic |
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