Detail
| LncRNA Name | DUXAP10 |
| Synonyms | PCAN-3 |
| Region | GRCh38_14:19294785-19337674 Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | bladder cancer |
| ICD-0-3 | C67 |
| Methods | qPCR, Western blot, RNAi |
| Sample | cell lines (5637, T24, E.j, TCCSUP,UM-UC.3, RT4, SV.HUC.1) |
| Expression Pattern | up-regulated |
| Function Description | the expression level of DUXAP10 was significantly enhanced in cancer cells..After knockdown of DUXAP10, cell proliferation was inhibited, cell cycle was arrested at G0/G1-phase, and apoptosis was increased in T24 and 5637-cells.knockdown of DUXAP10 decreased the expression of Bcl-xL, cyclin D and CDK4. This increased the expression of Bad, cleaved caspase-3, cleaved caspase-9, and p27.knockdown of DUXAP10 inhibited PI3K/Akt/mTOR signaling pathway. |
| Pubmed ID | 29115412 |
| Year | 2017 |
| Title | Knockdown of DUXAP10 inhibits proliferation and promotes apoptosis in bladder cancer cells via PI3K/Akt/mTOR signaling pathway. |
| External Links |
| Links for DUXAP10 | GenBank HGNC lncrnadb Noncode |
| Links for bladder cancer | Omim Cosmic |
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