Detail
| LncRNA Name | DUXAP8 |
| Synonyms | NA |
| Region | GRCh38_22:15784959-15829984 Sequence |
| Ensembl | ENSG00000206195 |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 M8046/3 |
| Methods | qPCR, RNAi, western blot |
| Sample | non small cell lung cancer tissues, cell lines (PC9, SPC-A1, NCI-H1975, H1299, and A549) |
| Expression Pattern | up-regulated |
| Function Description | We identified a transcribed pseudogene named DUXAP8 that is upregulated in tumor tissues. Patients with higher DUXAP8 expression exhibited shorter survival, suggesting DUXAP8 as a new candidate prognostic marker for NSCLC patients. Knockdown of DUXAP8 impairs cell growth, migration, and invasion, and induces apoptosis both in vitro and in vivo. |
| Pubmed ID | 28131418 |
| Year | 2017 |
| Title | The Pseudogene DUXAP8 Promotes Non-small-cell Lung Cancer Cell Proliferation and Invasion by Epigenetically Silencing EGR1 and RHOB |
| External Links |
| Links for DUXAP8 | GenBank HGNC lncrnadb Noncode |
| Links for non small cell lung cancer | Omim Cosmic |
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