Detail
| LncRNA Name | AFAP1-AS1 |
| Synonyms | AFAP1-AS1, AFAP1-AS, AFAP1AS, LOC84740, MGC10981 |
| Region | GRCh38_4:7754090-7778928 Sequence |
| Ensembl | ENSG00000272620 |
| RefSeq | NR_026892 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | retinoblastoma |
| ICD-0-3 | C69.2 M9510/3 |
| Methods | qPCR etc. |
| Sample | retinoblastoma tissues, cell lines (Weri-Rb1, Y79, ARPE-19 and HRMECs) |
| Expression Pattern | up-regulated |
| Function Description | In our results, AFAP1-AS1 expression was elevated in retinoblastoma tissues and cell lines, and associated with tumor size, choroidal invasion, and optic nerve invasion. Moreover, high expression of AFAP1-AS1 was an independent unfavorable prognostic factor in retinoblastoma patients. The experiment in vitro suggested down-regulation of AFAP1-AS1 inhibited retinoblastoma cell proliferation, migration and invasion, and blocked cell cycle. In conclusion, AFAP1-AS1 functions as an oncogenic lncRNA in retinoblastoma. |
| Pubmed ID | 29654169 |
| Year | 2018 |
| Title | LncRNA AFAP1-AS1 is a prognostic biomarker and serves as oncogenic role in retinoblastoma. |
| External Links |
| Links for AFAP1-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for retinoblastoma | Omim Cosmic |
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