Detail
| LncRNA Name | ECONEXIN |
| Synonyms | NA |
| Region | NA Sequence |
| Ensembl | NA |
| RefSeq | NA |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✘ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✔ |
| Methylation | ✔ |
| Cancer Name | glioma |
| ICD-0-3 | M9380/3 |
| Methods | Western blot, Microarray, luciferase reporter assay. |
| Sample | glioma tissue, glioma cell lines (U87,U251) |
| Expression Pattern | up-regulated |
| Function Description | Our data demonstrated that ECONEXIN is a potential oncogene that regulates TOP2A by sponging miR-411-5p in glioma. In addition, our investigative approaches to identify conserved lncRNA and their molecular characterization by validation in mouse tumor models may be useful to functionally annotate novel lncRNAs, especially cancer-associated lncRNAs.which coordinately promotes self-renewal by sponging miR-145 in the cytoplasm and recruiting polycomb to repress differentiation genes by the locus-specific methylation of histone H3K27 in the nucleus.promoter region (~500 bp upstream of transcriptional start site). Transcriptional factor binding motif analysis using the JASPAR database revealed that 140 transcription factors may bind to the ECONEXIN and C130071C03Rik promoter regions.28 |
| Pubmed ID | 28368417 |
| Year | 2017 |
| Title | Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis. |
| External Links |
| Links for ECONEXIN | GenBank HGNC lncrnadb Noncode |
| Links for glioma | Omim Cosmic |
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