Detail
| LncRNA Name | EGFR-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:55179750-55188934 Sequence |
| Ensembl | ENSG00000224057 |
| RefSeq | NR_047551 |
| Circulating | ✘ |
| Drug-resisitant | ✘ |
| Prognostic | ✔ |
| MiRNA | ✘ |
| Variant | ✘ |
| TF | ✘ |
| Methylation | ✘ |
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 M8170/3 |
| Methods | microarray, qPCR, RNAi, Western blot, Flow cytometry assay etc. |
| Sample | HCC tissues, cell lines (SMMC-7721, LM-9, Huh-7, HepG2) |
| Expression Pattern | up-regulated |
| Function Description | It was verified that EGFR and EGFR-AS1 were relatively upregulated in HCC tissue, and they were significantly related to some clinical characteristics and patient prognosis. Furthermore, EGFR-AS1 was determined to promote HCC development by improving the ability of invasion and proliferation of HCC cells in vitro, and it was also found to affect the cell cycle. Our study identified that EGFR-AS1 may promote HCC genesis and development. EGFR-AS1 may act as a prognostic factor in HCC. |
| Pubmed ID | 26271667 |
| Year | 2015 |
| Title | The long noncoding RNA, EGFR-AS1, a target of GHR, increases the expression of EGFR in hepatocellular carcinoma. |
| External Links |
| Links for EGFR-AS1 | GenBank HGNC lncrnadb Noncode |
| Links for hepatocellular carcinoma | Omim Cosmic |
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